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The reason for this restriction is that as previously described, the age-related decline in function of the GH neuroendocrine axis is accepted as being a normal part of aging, even though it is progressively detrimental to many aspects of body function

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GST non-enzymatic functions GSTs are also implicated as modulators of signal transduction pathways implicated in cell survival and apoptosis, where they control the activity of members of the mitogen-activated protein kinase (MAPK) family 24,25